MiraLAX (polyethylene glycol 3350)

MiraLAX can cause mild or serious side effects. The following list contains some of the key side effects that may occur while taking MiraLAX. This list does not include all possible side effects.

For more information on the possible side effects of MiraLAX, or tips on how to manage with a troubling side effect, talk with your doctor or pharmacist.

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More common side effects

The more common side effects of MiraLAX include:

• diarrhea or loose stools
• gas (flatulence)
• nausea
• stomach pain
• bloating

These side effects may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk with your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

• Dehydration: Diarrhea caused by MiraLAX can cause fluid loss and dehydration. Older adults have a higher risk of diarrhea and dehydration. Symptoms of dehydration include:
  • thirst
  • fatigue
  • dizziness
  • confusion
  • dry mouth
  • irritability
  • no tears when crying (in children)
  • no wet diapers for several hours (in children)
• Allergic reactions: Although not common, some people can have an allergic reaction to MiraLAX. In rare cases, allergic reactions can be severe and include anaphylaxis. Symptoms of allergic reaction can include:
  • rash
  • itchy skin
  • runny nose
  • difficulty breathing
  • swollen lips, tongue, or throat

Diarrhea

Diarrhea or loose stools are more common side effects of MiraLAX. Diarrhea is more likely to happen if you take more than the recommended dosage. Older adults (ages 65 years and older) also have a higher risk of diarrhea.

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For those who have diarrhea, the dosage may need to be reduced.

Bloating

Bloating is a common side effect of MiraLAX. This side effect was more common in studies of the drug. Bloating may decrease or go away with continued use of MiraLAX.

Nausea

Nausea is a more common side effect of MiraLAX. Nausea may decrease or go away with continued use of MiraLAX.

Weight gain

Some people have said they gained weight while taking MiraLAX. However, it’s not clear if MiraLAX is the cause of weight gain.

Headache

Some people have said they had headaches while taking MiraLAX. However, it’s not clear if MiraLAX is the cause of headaches.

Long-term side effects

The short- and long-term side effects of MiraLAX are similar. In a study lasting 6 months, the most common side effects of MiraLAX were:

• diarrhea or loose stools
• gas (flatulence)
• nausea
• stomach pain
• bloating

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Side effects are more likely to occur in the first weeks of MiraLAX use and may decrease over time.

Side effects in children

The same side effects that occur in adults can also happen in children.

There’s also some concern about other safety problems in children who take MiraLAX. There have been reports to the Food and Drug Administration (FDA) about unusual side effects in some children, such as:

• anger
• aggression
• changes in mood
• tremors
• seizures

These side effects have not occurred in clinical studies of MiraLAX in children, and it’s not clear if they’re caused by MiraLAX or something else. The FDA is funding additional research to investigate the concerns.

Following its 2014 Clinical Guidelines, the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) still recommends MiraLAX for the short- and long-term treatment of constipation in children.

If you have concerns about these side effects, talk with your doctor.

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