Tyrvaya (varenicline solution)

What is Tyrvaya (varenicline solution) for?

Tyrvaya (varenicline solution) is a highly selective cholinergic agonist indicated for the treatment of the signs and symptoms of dry eye disease.1

It is available in tablet form, each containing 60 sprays of varenicline solution.1

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How does Tyrvaya (varenicline solution) work?

Dry eye disease is a condition in which the eyes do not produce enough tears, or also when the eyes do not make the right type of tears or tear film. The parasympathetic nervous system, the “rest and digest” system, controls tear film homeostasis. It does so partially via the trigeminal parasympathetic pathway in the nose.2

The active ingredient in Tyrvaya, varenicline, is believed to activate the trigeminal parasympathetic pathway, thereby increasing tear film production. The exact mechanism of action of Tyrvaya is unknown at this time.2,3

Where has Tyrvaya (varenicline solution) been approved?

Tyrvaya (varenicline solution) was approved for the treatment of people with dry eye disease by:

• The Food and Drug Administration (FDA), USA on October 15, 2021.3

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Please note that this medicine may have also been approved in other regions than the ones we’ve listed. If you have a question about its approval in a specific country feel free to contact our support team.

How is Tyrvaya (varenicline solution) taken?

The standard dosage is:1

• One spray (0.03 mg) in each nostril twice daily (about 12 hours apart).

If you miss a dose, resume regular dosing at the next scheduled dose time.1

Complete information about Tyrvaya (varenicline solution) dosage (modifications) and administration can be found in the official prescribing information listed in our references section.1

Note: Please consult with your treating doctor for personalised dosing.

Are there any known adverse reactions or side effects of Tyrvaya (varenicline solution)?

Common adverse reactions

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The most common side effects (≥8% of patients) listed in the prescribing information include:1

• Sneezing
• Cough
• Throat irritation
• Nose irritation

Use in a specific population

It is not known if Tyrvaya (varenicline solution) can harm your unborn baby. In animal studies, the medicine did not have any harmful effects.1

For a comprehensive list of side effects and adverse reactions please refer to the official prescribing information.1

References

1. Full prescribing information [FDA]: Tyrvaya (varenicline solution) [PDF] Oyster Point Pharma, Oct 2021

2. Tyrvaya Tyrvaya-pro.com, cited Oct 2021

3. Oyster Point Pharma Announces FDA Approval of TYRVAYA™ (varenicline solution) Nasal Spray for the Treatment of the Signs and Symptoms of Dry Eye Disease Oyster Point Pharma, Oct 2021

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