Vyvanse (lisdexamfetamine dimesylate)

Vyvanse can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Vyvanse. These lists do not include all possible side effects.

For more information about the possible side effects of Vyvanse, talk with your doctor or pharmacist. They can give you tips on how to deal with any side effects that may be bothersome. You can also see this detailed article.

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Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to notify the FDA about a side effect you’ve had with Vyvanse, you can do so through MedWatch.

Mild side effects

Mild side effects* of Vyvanse can include:

• insomnia (trouble sleeping)
• decreased appetite
• abdominal pain
• nausea and vomiting
• anxiety†
• irritability†
• feeling jittery
• dizziness
• dry mouth
• weight loss†
• mood changes†
• constipation
• diarrhea
• headache†
• crashing (feeling tired or irritable as the effects of the drug wear off)†

Most of these side effects may go away within a few days or a couple of weeks. But if they become more severe or don’t go away, talk with your doctor or pharmacist.

* This is a partial list of mild side effects from Vyvanse. To learn about other mild side effects, talk with your doctor or pharmacist, or view Vyvanse’s Medication Guide. † For more information about this side effect, see “Side effect details” below.

Serious side effects

Serious side effects from Vyvanse aren’t common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.

Serious side effects and their symptoms can include:

• Cardiovascular (heart and blood vessel) problems. Examples include fast heartbeat, increased blood pressure, or in rare cases, heart attack, stroke, or sudden cardiac death (heart suddenly stops beating). Symptoms can include:
  • chest pain when exercising
  • dizziness
  • fainting for no apparent reason
  • feeling that your heart is pounding, racing, or skipping a beat
  • severe pain, pressure, or tightness in your chest, arm, throat, neck, or jaw
  • shortness of breath
  • nausea and vomiting
  • cold sweat
  • drooping on one side of the face
  • sudden weakness or numbness in one arm
  • slurred speech or trouble speaking
• Problems with blood circulation in your fingers and toes, such as Raynaud’s syndrome. Symptoms can include:
  • pale, blue, purple, or red fingers or toes
  • cold, numb, or painful fingers or toes
  • unexplained wounds on your fingers or toes
• Mental health conditions, such as psychosis or mania.*
• Serotonin syndrome (a dangerous condition caused by a buildup of serotonin in your body). Symptoms can include:
  • fast heartbeat
  • flushing
  • tremor or twitching
  • stiff muscles
  • loss of coordination
  • agitation
  • hallucinations
  • seizures
• Allergic reaction.*
• Potential for misuse and dependence.*†
• Slowed growth in children.‡

* For more information about this side effect, see “Side effect details” below. † Vyvanse has a boxed warning from the FDA regarding this side effect. A boxed warning is the strongest warning the FDA requires. It alerts doctors and patients about drug effects that may be dangerous. ‡ For more information about this side effect, see “Side effects in children” below.

Side effects in children

Vyvanse is used to treat ADHD in children ages 6 years and older. In clinical trials, most side effects of Vyvanse seen in children were similar to those seen in adults taking the drug. These are listed above and described in the “Side effect details” section below.

However, certain side effects may be more common in children taking this drug than in adults. These side effects are described below.

Weight loss in children

Children who take Vyvanse are more likely to have a decrease in appetite than adults who take this drug. They are also more likely to have weight loss than adults. Over time, this can lead to slowed growth in children.

In children ages 6 to 12 years who took Vyvanse every day for a year in clinical trials, weight loss led to slowed growth. This was assessed using growth charts that compare average body weight in children of the same sex and age. Before treatment, children in the study were, on average, in the 70th percentile for body weight. After taking Vyvanse for 1 year, these children were, on average, in the 47th percentile for body weight.

Children who take Vyvanse should have their height and weight regularly checked by their doctor. If your child’s growth is affected by this drug, their doctor may suggest taking a break from treatment. This will allow your child’s growth to catch up. To learn more about weight loss associated with Vyvanse, see “Weight loss” under “Side effect details” below.

Effects on personality in children

Vyvanse can sometimes cause irritability, anger, or mood changes in children. In clinical trials of children ages 6 to 12 years with ADHD:

• 10% of children who took Vyvanse experienced irritability
• 3% of children who took Vyvanse had mood changes

Neither of these side effects occurred in children taking a placebo in the studies. It’s not known how often irritability or mood changes occur in older children taking Vyvanse.

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If your child seems irritable or angry, or has mood changes or emotional breakdowns (intense emotional distress) while taking Vyvanse, talk with their doctor. They can help you find ways to manage their symptoms, or they may suggest switching your child to a different drug.

Side effect details

You may wonder how often certain side effects occur with this drug. Here’s some detail on certain side effects this drug may cause.

Allergic reaction

As with most drugs, some people can have an allergic reaction after taking Vyvanse. However, it’s not known how often this may have occurred in clinical studies. Symptoms of a mild allergic reaction can include:

• skin rash
• itchiness
• flushing

A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:

• swelling under your skin, typically in your eyelids, lips, hands, or feet
• swelling of your tongue, mouth, or throat
• trouble breathing

Call your doctor right away if you have an allergic reaction to Vyvanse, as the reaction could become severe. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.

Weight loss

Vyvanse may cause a decreased appetite or loss of appetite. For some people, this can lead to weight loss over time.

In clinical trials of ADHD, weight loss occurred in:

• 3% to 4% of adults who took Vyvanse
• 9% of children who took Vyvanse
• 0% to 1% of adults and children who took a placebo (treatment containing no active drug)

After 4 weeks of treatment, the average weight loss in people who took Vyvanse was:

• 2.8 pounds (lb) to 4.3 lb (1.3 kilograms [kg] to 2 kg) in adults
• 2.7 lb to 4.8 lb (1.2 kg to 2.2 kg) in children ages 13 to 17 years
• 0.9 lb to 2.5 lb (0.4 kg to 1.1 kg) in children ages 6 to 12 years

The amount of weight lost depended on dose, with more weight loss seen in people who took higher doses of Vyvanse.

In comparison, people who took a placebo in these studies tended to gain weight. After 4 weeks of treatment, the average weight gain was:

• 0.5 lb (0.2 kg) in adults
• 2 lb (0.9 kg) in children ages 13 to 17 years
• 1 lb (0.4 kg) in children ages 6 to 12 years

To learn about weight loss in adults who took Vyvanse for binge eating disorder, see the drug’s prescribing information.

If you’re concerned about weight loss with Vyvanse, talk with your doctor. For more information about weight loss in children, see the “Side effects in children” section above.

Note: Although Vyvanse can cause weight loss, it shouldn’t be taken specifically for weight loss or to treat obesity. It’s not FDA-approved or recommended for this use because of the risk of serious side effects.

Effects on personality

Vyvanse can sometimes have a temporary effect on personality, causing changes in a person’s thoughts or behavior. For instance, Vyvanse can sometimes cause irritability, anger, or mood changes, particularly in children. (See the “Side effects in children” section above to learn more about this side effect in children.)

In rare instances, stimulants such as Vyvanse can cause or worsen serious mental health conditions. These include psychosis or mania in children and adults.

In clinical trials involving different types of stimulants:

• 0.1% of people who took stimulants had symptoms of psychosis or mania
• 0% of people who took a placebo (a treatment containing no active drug) had symptoms of psychosis or mania

Symptoms of psychosis can include hallucinations, paranoia, and delusions (believing things that aren’t true). Symptoms of mania can include severe insomnia (trouble sleeping), racing thoughts, impulsive or reckless behavior, and extreme levels of happiness, excitement, or activity.

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If you or your child have any of these symptoms or other changes in thoughts or behavior while taking Vyvanse, talk with your doctor right away. They may recommend stopping Vyvanse.

Crashing

A Vyvanse crash refers to side effects that can happen when the effects of Vyvanse start to wear off. These are also known as withdrawal symptoms. They may include:

• feeling tired
• extreme fatigue (lack of energy)
• irritability
• depression

It’s not known how often crashing may occur in people who take Vyvanse. Some people who take Vyvanse in the morning may have these symptoms toward the end of the day. However, Vyvanse is a long-acting stimulant that lasts all day to treat symptoms. It’s less likely to cause a crash than short-acting stimulants that wear off after a few hours.

If you find the effects of Vyvanse wear off too soon or you have symptoms of crashing, talk with your doctor. They may suggest ways to manage this, or they may recommend a different treatment.

Headache

Vyvanse may cause headaches in some people who take this drug. Headaches are common side effects of stimulant drugs such as Vyvanse.

In clinical trials, 1% of adults who took Vyvanse stopped treatment because of headaches. It’s not known how often headaches may have occurred in children or adults who took a placebo in these studies.

If you have bothersome headaches while taking Vyvanse, talk with your doctor about ways to manage them. You can typically take acetaminophen (Tylenol) to treat a headache while taking Vyvanse.

Anxiety

Some people may have anxiety while taking Vyvanse. In clinical trials, anxiety was reported in:

• 5% to 6% of adults who took Vyvanse, depending on the condition being treated
• 0% to 1% of adults who took a placebo (a treatment containing no active drug)

It’s not known how often anxiety may have occurred in children who took Vyvanse in clinical studies.

If you have anxiety while taking Vyvanse, talk with your doctor. They can suggest ways to help manage this side effect.

Misuse

Vyvanse is a stimulant medication that has a high risk of drug misuse.* Drug misuse is taking a drug for a nonmedical use, or in a way that’s not approved. This is typically done to produce a “high.” Drug misuse typically involves using higher doses of a drug than are prescribed for medical uses.

Vyvanse use also has a high risk of physical and psychological dependence, meaning you need the drug to function like usual. As a result, people may try to get Vyvanse illegally.

Vyvanse may have a lower risk of misuse than some other stimulant drugs. This is because it doesn’t work until it’s been activated in your body. Vyvanse doesn’t have a fast or intense effect, unlike some other stimulants.

However, you should keep Vyvanse in a safe place, such as a locked cabinet, to help prevent other people from misusing this drug. It’s illegal to give or sell Vyvanse to someone who doesn’t have a prescription for it. Misuse of Vyvanse can cause serious side effects, including heart problems and, in some cases, death.

It’s not known how often misuse or dependence may occur in people who take Vyvanse as prescribed for ADHD or binge eating disorder.

You should take Vyvanse exactly as your doctor prescribes it. Do not take a higher dose, take it more often, or take it for longer than prescribed. If you’ve ever misused or been dependent on alcohol, prescription drugs, or illegal drugs, tell your doctor before taking Vyvanse.

* Vyvanse has a boxed warning for this side effect. A boxed warning is the strongest warning the FDA requires. It alerts doctors and patients about drug effects that may be dangerous.

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