Pill Pneumonitis Induced By Pill Aspiration: A Case Report, Diagnosis and Management

Swarada Yadav*, Sundeep Shah, Sumaita Waqar, Ramy Ibrahim

Internal Medicine, University of Alabama at Birmingham, Birmingham, USA

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*Corresponding Author: Swarada Yadav, Internal Medicine, University of Alabama at Birmingham, Birmingham, USA

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Abstract Pill pneumonitis is a rare and life-threatening disease caused by the aspiration of a medication pill. Our case is about a 71-year-old male who presented in the Emergency Department (ED) with a complaint of choking on a Vitamin D pill. Computed Tomography (CT) scan revealed a round foreign body consistent with an aspirated pill in the bronchus intermedius. When the patient underwent bronchoscopy on day two, the pill disintegrated causing local inflammation. The patient was stabilized and treated symptomatically and referred to a tertiary care center for further evaluation. The patient went to a tertiary center three weeks later with persistent complaints of hemoptysis, cough, and shortness of breath. Bronchoscopy revealed mucosal irregularity with protruding non-bleeding vessels on the posterior wall. The mucosa was extremely friable and easy to bleed. The patient was treated at the tertiary hospital and discharged with minimum residual symptoms. Three months later the patient showed up at the primary care physician’s (PCP) office with hemoptysis, cough, and shortness of breath. On examination, he still had residual wheezing and rhonchi. The patient was prescribed codeine and guaifenesin syrup along with budesonide suspension via inhalation which provided symptomatic relief to the patient. The patient’s condition can be managed long-term symptomatically but airway healing is not possible due to underlying permanent fibrosis.

This case highlights the importance of swift initiation of treatment in cases involving pill aspiration as the pill could disintegrate quickly leading to incurable permanent airway damage. Prompt management includes rapid attempts to remove the pill along with symptomatic relief agents like nebulizers and steroids.

Introduction Accidental pill aspiration while swallowing a pill is an emergency due to the fear of mucosal injury and inflammation [1]. It can lead to life-threatening consequences [1]. Elderly and young children are at higher risk of aspiration [2]. Patients with swallowing disorders are also prone to aspirate pills while swallowing [3]. Aspiration of a pill may usually present with sudden dyspnea, dry cough, rhinorrhea, unusual sensation in the chest, and other nonspecific symptoms [4]. The final diagnosis is usually made based on the history, evidence of acute symptoms of distress, and presence of a foreign body during bronchoscopy or CT scan [5]. Treatment usually focuses on the immediate removal of the pill to reverse the inflammation and reduce the symptoms [6]. An emergency bronchoscopy with an attempt to remove the pill is the most ideal way to manage such patients with known aspirations [4]. Time is a key factor while managing these patients.

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Case Presentation A 71- year-old male with a past medical history of swallowing disorder presented to the Emergency Room with the complaint of choking on a Vitamin D pill. The patient had a history of worsening coughing and choking when he drank or ate pills. When he aspirated the pill, he tried to cough it out but failed to do so. On arrival, the patient had a saturation of peripheral oxygen (SpO2) of 89 % and blood pressure of 136/84. The rest of the vitals were stable. A lung examination showed bronchial wheezing on the right side. The patient was started on a nebulizer which improved the SpO2 to 92 %. Supplemental oxygen was used to maintain the oxygen level above 94 %. The patient was further evaluated with a CT scan of the chest which revealed a 12 mm round foreign body, consistent with an aspirated pill in the bronchus intermedius. The rest of the lung was free of any infiltrate, effusion, or pneumothorax. Pulmonary consultation was requested to further evaluate and manage the patient. Bronchoscopy was performed on day two. Bronchoscopy revealed severe bronchospasm. The mucosa in the right bronchus was white and seemed to show some extent of mucosal damage. Endobronchial biopsy showed benign bronchial mucosa with focal congestion. Bronchial lavage showed no growth at 24 hours. Minimal bleeding was seen during the procedure. No pill was noted in the airway. On day three of the hospitalization, the patient was stable with wheezing improved on the right side. The patient was discharged home with steroids and instructions to use the nebulizer. The patient was referred to a tertiary center for possible cryotherapy and injectable steroids.

Three weeks later the patient went to a tertiary center outpatient department with a history of recurrent episodes of hemoptysis. On arrival, the patient had all vitals stable with SpO2 of 94 % and respiratory rate of 20 respirations/minute. Chest X-ray (CXR) showed right-sided opacities. Pulmonary angiogram showed branching filling defect in multiple left lower lobe segmental pulmonary artery branches. For further evaluation bronchoscopy was performed which showed normal nasopharynx, oropharynx, larynx, vocal cords, and left lung but revealed mucosal irregularity with protruding non- bleeding vessels on the posterior wall. The mucosa was extremely friable and easy to bleed. After stabilization of the patients with IV fluids and IV steroids for a week, a repeat bronchoscopy was done which showed bronchial stenosis, the dynamic collapse of the tracheobronchial tree, and granulation tissue in the bronchial intermedius. Cryotherapy was done to prevent bleeding, after which the patient appeared stable over the next couple of days with improved breathing and no events of hemoptysis. The patient was deemed fit for discharge. Upon discharge, the patient was asked to continue to take a step-down dosage of steroids, benzonatate, and cough syrup with codeine as needed.

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