Mounjaro vs. Wegovy: Which Works Best?

What is Mounjaro?

Mounjaro is the brand name for the medication tirzepatide, which was approved by the FDA in May of 2022 for the treatment of type 2 diabetes. Mounjaro, which is manufactured by the pharmaceutical company Eli Lilly, belongs to a class of drugs called glucagon-like peptide-1 (GLP-1) receptor agonists, which help in regulating blood sugar levels.

Mounjaro, which is administered as a weekly injection, works by simultaneously activating two different types of receptors in the body: the glucagon-like peptide-1 (GLP-1) receptor and the glucose-dependent insulinotropic polypeptide (GIP) receptor. In simpler terms, the medication helps with several important functions:

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• Helping your pancreas: Your pancreas controls how much sugar is in your blood via a hormone called insulin, but if you have type 2 diabetes, your pancreas struggles to control how much insulin to release. Mounjaro helps your pancreas release insulin when your blood sugar is high, which lowers your blood sugar levels.
• Slowing down food absorption: When you eat, food breaks down into sugar, which goes into your blood. Mounjaro slows this process down, so sugar enters your bloodstream more slowly. It’s like telling a crowd of people to enter a concert venue in an orderly line instead of all rushing in at once.

In general, higher doses of tirzepatide — the active ingredient in Mounjaro — are also shown to produce significant effects on body weight, but it isn’t indicated for weight loss. In other words, while weight loss is a side effect of Mounjaro, prescribing it for weight loss is an off-label use of the medication.

What is Wegovy?

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Wegovy, another GLP-1 receptor agonist, contains the active ingredient semaglutide (which is also found in Ozempic, a similar medication). Unlike Mounjaro, Wegovy was FDA-approved in June of 2021 specifically for adults with obesity, or those who are overweight with weight-related health conditions like high blood pressure, high cholesterol, or type 2 diabetes.

Like Mounjaro, Wegovy is administered via a weekly injection, and its primary action is to mimic the incretin hormones, which increases insulin production and lowers blood sugar levels. It has shown significant effectiveness in weight reduction, especially when combined with lifestyle changes.

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