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I know this is super old but I’ve recently solidified my theory that Wellbutrin (XL OR SR) causes acne in some individuals! I went on a low dosage of Wellbutrin 4 years ago and have been consistently on the same dosage since. I started developed cystic acne on my chin (typically during my menstrual cycle) during that time period. Until now I was unable to accredit it to Wellbutrin specifically because I was 22 when the hormonal cysts commenced and thus I wouldn’t be surprised that a hormonal shift would occur during that age period.

With that said, I began using AHAs/BHAs over the summer and have eliminated my occasional hormonal cysts. (They are huge and under the skin! About the size of a dime! The rest of my skin is clear.) My skin has been essentially perfect (minus red marks and skin barrier damage) until approximately 3 weeks ago when my doctor upped my Wellbutrin for the first time in 4 years. Within 2 weeks, I had 2 large cysts pop-up on my chin. (I upped the dosage from a low 150 MG to 225 MG.) I thought this was unusual as I typically only have one but began the healing process. Around 3 evenings ago, I had 2 more massive inflamed areas erupt from under my skin and I noticed four cysts appear on my neck/jaw area. I have never had any pimples anywhere besides my face. I have never had more than 2 cysts at once and as aforementioned, I’d never had any prior to taking Wellbutrin.

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I changed nothing else in my routine and am absolutely positive it’s the Wellbutrin. I performed some mild google research and discovered threads of people correlating Wellbutrin with acne.

With that said, I lowered back to my original dosage today and am hoping I can speed up my skin’s natural cycle with BHA’s until these surface. I will update this post to confirm that my skin returns to its “normal” state in the next several weeks.

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Anyone else had this negative experience with Wellbutrin?

PS: I’ve spoken to my psychiatrist about this and he agreed that it’s possible. Unfortunately he’s not a scientist and therefore cannot suggest to me the reason (mechanism of action) that the Wellbutrin would affect otherwise healthily functioning skin in this way. If anyone is a chemist or such I would be really fascinated to hear how this happens.

Thank you!

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